Abstract

Knowing how cells respond to DNA damage is critical to our understanding of tumourigenesis, genomic instability, and the cellular response to DNA-damaging chemotherapy and radiotherapy. DNA damage responses take place in the context of chromatin and in the midst of ongoing transcription and replication. Moreover, the metabolic environment, which is altered in tumour cells, influences these activities. In this conference, we aim to bring together researchers working on understanding DNA damage responses in the context of complex and dynamic cellular environments. This is an exciting and fast moving area, and this conference features an excellent international line-up of speakers. The programme will address the challenges of understanding this complex field and will emphases new experimental approaches for interrogating these pathways. We will also consider how recent advances can be exploited in the clinic.